Carole CHAIX
Interfaces & Biosensors, Group Leader
CNRS Director of research
Contact
carole.chaix[@]univ-lyon1.fr
ResearchGate/ Carole_ChaixResearch
- Development of rapid, low-cost and multiplexed assays for either in-situ analyses, point-of-care diagnostics and/or personalized medicine. Electrochemical sensors based on carbon or gold electrodes. Redox-labeled biomolecules for electrochemical detection.
- Multi-functionalized nanoparticles for in vitro diagnostics and in vivo imaging and therapy.
Biography
Carole Chaix is Director of Research at the Centre National de la Recherche Scientifique (CNRS). She graduated from the University of Grenoble where she obtained a Master in Biological and Medical Engineering in 1987 and a Ph.D. degree in 1990. She started her career as academic Researcher at the University of Montpellier in 1991. After four years in Montpellier and one year spent at the Hybridon company in Boston (US), where she was involved in the development of antisense oligonucleotides for cancer therapy, she moved to the Ecole Normale Supérieure de Lyon (ENS) to work in the CNRS-bioMérieux research unit. Her research activities were focused on the development of innovative approaches for in vitro diagnostics. In 2008, she joined the Institute of Analytical Sciences to work on biosensors.
Carole Chaix has a strong experience in developing innovative approaches, tools and devices for the detection of a wide range of biological targets (DNA, proteins, antibodies, bacteria, viruses,…) in biological samples. Her skills relate to biomolecule synthesis, labeling and immobilization on various supports such as plastics, polymers, silica, glass and metals. She is currently involved in the development of potential-assisted grafting reactions for addressing biomolecules on gold and carbonaceous materials. She is also interested in the elaboration of multi-functionalized nanoparticles to improve the sensitivity of biosensors. Carole Chaix has coordinated several National projects dedicated to the development of in vitro tests for biomedical diagnosis. She is currently the co-author of more than 80 publications (h-index = 23) and 8 patents.
Keywords
Biosensor; Bioconjugate; Nanotechnology; Interface; Electrochemical detection; multidetection; Methylene blue; Ferrocene; DNA; Nanomedicine; Nanostructuration; Diamond; Gold; Graphene; multi-functionalization;
Publications
Articles in peer-review journals since 2011
2023
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- Francesco Rizzotto, Majd Khalife, Yanxia Hou, Carole Chaix, Florence Lagarde, et al.. Recent Advances in Electrochemical Biosensors for Food Control. Micromachines, 2023, 14 (7), pp.1412. ⟨10.3390/mi14071412⟩. ⟨hal-04172926⟩
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- Vanessa Escobar, Natale Scaramozzino, Jasmina Vidic, Arnaud Buhot, Raphaël Mathey, et al.. Recent Advances on Peptide-Based Biosensors and Electronic Noses for Foodborne Pathogen Detection. Biosensors, 2023, 13 (2), pp.258. ⟨10.3390/bios13020258⟩. ⟨hal-03991410⟩
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- Ivan Kucherenko, Carole Farre, Gaetan Raimondi, Carole Chaix, Nicole Jaffrezic-Renault, et al.. A novel adenosine triphosphate (ATP) biosensor based on electrospun polymer nanofibers with entrapped hexokinase and glucose oxidase. Applied Nanoscience, 2023, ⟨10.1007/s13204-023-02861-y⟩. ⟨hal-04121224⟩
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2022
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- Meryem Belkilani, Carole Farre, Yves Chevalier, Sylvain Minot, François Bessueille, et al.. Mechanisms of Influenza Virus HA2 Peptide Interaction with Liposomes Studied by Dual-Wavelength MP-SPR. ACS Applied Materials & Interfaces, 2022, ⟨10.1021/acsami.2c09039⟩. ⟨hal-03730479⟩
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- Ludivine Taiariol, Carole Chaix, Carole Farre, Emmanuel Moreau. Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?. Chemical Reviews, 2022, 122 (1), pp.340-384. ⟨10.1021/acs.chemrev.1c00484⟩. ⟨hal-03406814⟩
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- Arthur Degasperi, Lucie Labied, Carole Farre, Emmanuel Moreau, Matteo Martini, et al.. Probing the protein corona of gold/silica nanoparticles by Taylor dispersion analysis-ICP-MS. Talanta, 2022, 243, pp.123386. ⟨10.1016/j.talanta.2022.123386⟩. ⟨hal-03663936⟩
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2021
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- Meryem Belkilani, Maryam Shokouhi, Carole Farre, Yves Chevalier, Sylvain Minot, et al.. Surface Plasmon Resonance Monitoring of Mono-Rhamnolipid Interaction with Phospholipid-Based Liposomes. Langmuir, 2021, 37 (26), pp.7975-7985. ⟨10.1021/acs.langmuir.1c00846⟩. ⟨hal-03282399⟩
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- Yannick Bleu, Florent Bourquard, Carole Farre, Carole Chaix, Jules Galipaud, et al.. Boron doped graphene synthesis using pulsed laser deposition and its electrochemical characterization. Diamond and Related Materials, 2021, 115, pp.108382. ⟨10.1016/j.diamond.2021.108382⟩. ⟨hal-03187937⟩
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- Priya Vizzini, Marisa Manzano, Carole Farre, Thierry Meylheuc, Carole Chaix, et al.. Highly sensitive detection of Campylobacter spp. In chicken meat using a silica nanoparticle enhanced dot blot DNA biosensor. Biosensors and Bioelectronics, 2021, 171, pp.112689. ⟨10.1016/j.bios.2020.112689⟩. ⟨hal-02972078⟩
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2020
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- Carole Farre, Sara Viezzi, Alice Wright, Perrine Robin, Nathalie Lejal, et al.. Specific and sensitive detection of Influenza A virus using a biotin-coated nanoparticle enhanced immunomagnetic assay. Analytical and Bioanalytical Chemistry, 2020, ⟨10.1007/s00216-020-03081-x⟩. ⟨hal-03033697⟩
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- Jasmina Vidic, Carole Chaix, Marisa Manzano, Marc Heyndrickx. Food Sensing: Detection of Bacillus cereus Spores in Dairy Products. Biosensors, 2020, 10 (3), pp.15. ⟨10.3390/bios10030015⟩. ⟨hal-02550769⟩
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2019
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- Florent Bourquard, Yannick Bleu, Anne-Sophie Loir, Borja Caja-Munoz, José Avila, et al.. Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing. Materials, 2019, 12 (4), pp.666. ⟨10.3390/ma12040666⟩. ⟨emse-04000569⟩
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- Ludivine Vossier, Lionel Valera, Fanny Leon, Stéphanie Roche, Dominique Piquer, et al.. Combining culture and microbead-based immunoassay for the early and generic detection of bacteria in platelet concentrates. Transfusion, 2019, 59 (1), pp.277-286. ⟨10.1111/trf.15019⟩. ⟨hal-01934702⟩
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- Florent Bourquard, Yannick Bleu, Anne-Sophie Loir, Borja Caja-Munoz, José Avila, et al.. Electroanalytical Performance of Nitrogen-Doped Graphene Films Processed in One Step by Pulsed Laser Deposition Directly Coupled with Thermal Annealing. Materials, 2019, 12 (4), pp.666. ⟨10.3390/ma12040666⟩. ⟨hal-02048851⟩
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2018
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- Gabriel de Crozals, David Kryza, Gloria Jiménez Sánchez, Stéphane Roux, Doriane Mathé, et al.. Granulocyte Colony-Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part I): Synthesis and Biodistribution Studies. Bioconjugate Chemistry, 2018, 29 (3), pp.795 - 803. ⟨10.1021/acs.bioconjchem.7b00605⟩. ⟨hal-01767382⟩
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- Romaric Bonnet, Carole Farre, Lionel Valera, Ludivine Vossier, Fanny Leon, et al.. Highly labeled methylene blue-ds DNA silica nanoparticles for signal enhancement of immunoassays: application to the sensitive detection of bacteria in human platelet concentrates. Analyst, 2018, 143 (10), pp.2293-2303. ⟨10.1039/c8an00165k⟩. ⟨hal-01859171⟩
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- David Kryza, Gabriel de Crozals, Doriane Mathé, Jacqueline Taleb Sidi-Boumedine, Marc Janier, et al.. Granulocyte-Colony Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part II): Dose-Dependent Biodistribution and In Vivo Antitumor Efficacy in Combination with Rituximab. Bioconjugate Chemistry, 2018, 29 (3), pp.804 - 812. ⟨10.1021/acs.bioconjchem.7b00606⟩. ⟨hal-01767371⟩
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- Estelle Lebegue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Biomimetic vesicles for electrochemical sensing. Current Opinion in Electrochemistry, 2018, 12 (12), pp.101-106. ⟨10.1016/j.coelec.2018.06.005⟩. ⟨hal-01928207⟩
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- Estelle Lebègue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Responsive Polydiacetylene Vesicles for Biosensing Microorganisms. Sensors, 2018, 18 (2), pp.599. ⟨10.3390/s18020599⟩. ⟨hal-01740158⟩
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2016
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- Philippe Fortgang, Teddy Tite, Vincent Barnier, Nedjla Zehani, Chiranjeevi Maddi, et al.. Robust Electrografting on Self-Organized 3D Graphene Electrodes. ACS Applied Materials & Interfaces, 2016, 8 (Issue : 2), pp.1424-1433. ⟨10.1021/acsami.5b10647⟩. ⟨emse-01496461⟩
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- Ali Houmed Adabo, Rabah Zeggari, Nasser Mohamed Said, Rana Bazzi, Céline Elie-Caille, et al.. Enhanced chemiluminescence-based detection on gold substrate after electrografting of diazonium precursor-coated gold nanoparticles. Journal of Colloid and Interface Science, 2016, 467, pp.271-279. ⟨10.1016/j.jcis.2016.01.030⟩. ⟨hal-01363650⟩
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- Mohamed Braiek, Yi Yang, Carole Farre, Carole Chaix, François Bessueille, et al.. Boron-doped Diamond Electrodes Modified with Fe 3 O 4 @Au Magnetic Nanocomposites as Sensitive Platform for Detection of a Cancer Biomarker, Interleukin-8.. Electroanalysis, 2016, 28 (8), pp.1810-1816. ⟨10.1002/elan.201600060⟩. ⟨hal-01546541⟩
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- Gabriel de Crozals, Romaric Bonnet, Carole Farre, Carole Chaix. Nanoparticles with multiple properties for biomedical applications: A strategic guide. Nano Today, 2016, 11 (4), pp.435-463. ⟨10.1016/j.nantod.2016.07.002⟩. ⟨hal-01546542⟩
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- Mengjuan Jiang, Mohamed Braiek, Carole Farre, Anne Bonhommé, Carole Chaix, et al.. Effect of Perfluorinated-Hexaethylene Glycol Functionalization of Gold Nanoparticles on the Enhancement of the Response of an Enzymatic Conductometric Biosensor for Urea Detection. Current Bionanotechnology, 2016, 1 (2), pp.110-115. ⟨hal-01363651⟩
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2015
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- Gabriel de Crozals, Carole Farre, Monique Sigaud, Philippe Fortgang, Corinne Sanglar, et al.. Methylene blue phosphoramidite for DNA labelling. Chemical Communications, 2015, 51 (21), pp.4458-4461. ⟨10.1039/c4cc10164b⟩. ⟨hal-01187184⟩
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- Lucian-Gabriel Zamfir, Philippe Fortgang, Carole Farre, Micaël Ripert, Gabriel de Crozals, et al.. Synthesis and electroactivated addressing of ferrocenyl and azido-modified stem-loop oligonucleotides on an integrated electrochemical device. Electrochimica Acta, 2015, 164, pp.62-70. ⟨10.1016/j.electacta.2015.02.167⟩. ⟨hal-01227342⟩
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2014
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- Nadir Meini, Micaël Ripert, Carole Chaix, Carole Farre, Gabriel de Crozals, et al.. Label-free electrochemical monitoring of protein addressing through electroactivated "click" chemistry on gold electrodes. Materials Science and Engineering: C, 2014, 38, pp.286-291. ⟨10.1016/j.msec.2014.02.013⟩. ⟨hal-00954571⟩
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2013
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- Myriam Lereau, Chantal Fournier-Wirth, Julie Mayen, Carole Farre, Albert Meyer, et al.. Development of Innovative and Versatile Polythiol Probes for Use on ELOSA or Electrochemical Biosensors: Application in Hepatitis C Virus Genotyping. Analytical Chemistry, 2013, 85, pp.9204−9212. ⟨10.1021/ac401941x⟩. ⟨hal-00874608⟩
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- Micaël Ripert, Carole Farre, Carole Chaix. Selective functionalization of Au electrodes by electrochemical activation of the "click" reaction catalyst. Electrochimica Acta, 2013, 91, pp.82-89. ⟨10.1016/j.electacta.2012.12.108⟩. ⟨hal-00878554⟩
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2012
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- Gabriel de Crozals, Carole Farre, Grégoire Hantier, Didier Léonard, Christophe A. Marquette, et al.. Oligonucleotide solid-phase synthesis on fluorescent nanoparticles grafted on controlled pore glass. RSC Advances, 2012, 2 (31), pp.11858-11866. ⟨10.1039/c2ra22077f⟩. ⟨hal-00816504⟩
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- Gaëlle Le Goff Le Goff, Benjamin Corgier, Celine Mandon, Gabriel de Crozals, Carole Chaix, et al.. Impact of immobilization support on colorimetric microarrays performances. Biosensors and Bioelectronics, 2012, 35 (1), pp.94-100. ⟨10.1016/j.bios.2012.02.025⟩. ⟨hal-02113278⟩
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- Grégory Chatelain, Micaël Ripert, Carole Farre, Salomé Ansanay-Alex, Carole Chaix. A "four-ferrocene" modified stem-loop structure as a probe for sensitive detection and single-base mismatch discrimination of DNA. Electrochimica Acta, 2012, 59, pp.57-63. ⟨10.1016/j.electacta.2011.10.030⟩. ⟨hal-00698518⟩
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- N. Meini, Carole Farre, Carole Chaix, R. Kherrat, Sergei V. Dzyadevych, et al.. A sensitive and selective thrombin impedimetric aptasensor based on tailored aptamers obtained by solid-phase synthesis. Sensors and Actuators B: Chemical, 2012, 166, pp.715-720. ⟨10.1016/j.snb.2012.03.046⟩. ⟨hal-00816495⟩
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2011
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- Grégory Chatelain, Albert Meyer, François Morvan, Jean-Jacques Vasseur, Carole Chaix. Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate α-oligonucleotides. New Journal of Chemistry, 2011, 35 (4), pp.893-901. ⟨10.1039/C0NJ00902D⟩. ⟨hal-00986717⟩
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Direction of books or issues of journals – books – book chapters
2019
Book sections
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- F Bourquand, C Donnet, Florence Garrelie, A.-S. Loir, Francis Vocanson, et al.. Self-organized 3D graphene as a robust sensing platform. in Palys Barbara (Ed). Handbook of Graphene, Volume 6: Biosensors and Advanced Sensors, John Wiley & Sons, pp.481-506, 2019, 978-1-119-46974-2. ⟨hal-02113527⟩
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2017
Books
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- Carole Farre, Gaëtan Raimondi, Carole Chaix, Nicole Jaffrezic-Renault, Oleksandr O Soldatkin, et al. (Dir.). Gold Nanoparticle/Polymer/Enzyme Nanocomposite for the Development of Adenosine Triphosphate Biosensor. in Eds. Fesenko O, Yatsenko L. Springer Proceedings in Physics, 195, pp.533-545, 2017, Nanophysics, Nanomaterials, Interface studies and Applications - Selected proceedings of the 4th International Research and Practice Conference on Nanotechnology and Nanomaterials (NANO 2016), 978-3-319-56422-7; 978-3-319-56244-5. ⟨10.1007/978-3-319-56422-7_39⟩. ⟨hal-01859674⟩
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