Marion GIROD

Doctor
work phone: 0437423678

Research

My current research activity at the Institute for Analytical Sciences (ISA) in the AnabioMS team is focused on the coupling of optical spectroscopy with mass spectrometry. I am especially interested with these tools, to improve the identification and the quantification of protein biomarkers in complex biological matrices, crucial in a context of population ageing. Because of this, I participate in the theme ‘health’ of the ISA. These optical tools are also used for the structural characterization of proteins. Through this, my activity strongly benefits from close collaboration with the Institute of Light Material (ILM) Lyon, especially with P. Dugourd team.

Biography

Marion Girod is a research scientist at the France’s national scientific research center (CNRS) since 2011. She received an Msc degree in Analytical Chemistry from University of Lyon 1 in 2007. Her PhD research focused on the use of tandem mass spectrometry for structural characterization of synthetic co-polymers and was completed in the group of Laurence Charles in 2009 at the University of Marseille. From 2009-2010, Marion was a postdoctoral fellow at the University of Purdue (USA) in the group of R. Graham Cooks, where she was working on imaging of biological tissues with DESI-MS. She then joined University Claude Bernard Lyon 1 for a post-doctorate in the group of Philippe Dugourd, where she dedicated her research to the optical characterization of an electrospray source by fluorescent measurements. In 2011, she became researcher at the Institute of Analytical Sciences where she was involved in the coupling of mass spectrometry with optical spectroscopy for characterization and quantification of biomolecules. She was involved in two ANR. In 2018, she obtained a Young Researcher ANR Grant for the project HyLOxi, to use laser induced dissociation coupled with mass spectrometry to monitor oxidative stress. She was the co-supervisor or the supervisor of 5 PhD students and 6 M.Sc. Students, and authored 41 publications, with more than 40 communications in national and international conferences. She is member of the editorial board of Rapid Communication in Mass Spectrometry since 2013. She was elected member of the regional board of the French Chemical Society (SCF) in 2016.
She is member of the Institute council and Security and Health council at ISA.

Keywords

Mass spectrometry; optical spectroscopy; laser induced dissociation, chromophore derivatization, protein biomarkers

Publications

Publications HAL de Marion,Girod

2018

Journal articles

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Luke Macaleese, Marion Girod, Laurent Nahon, Alexandre Giuliani, Rodolphe Antoine, et al.. Radical Anions of Oxidized vs. Reduced Oxytocin: Influence of Disulfide Bridges on CID and Vacuum UV Photo-Fragmentation. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2018, 29 (9), pp.1826-1834. ⟨10.1007/s13361-018-1989-8⟩. ⟨hal-01864504⟩
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Lény Garcia, Marion Girod, Magali Rompais, Philippe Dugourd, Christine Carapito, et al.. Data-Independent Acquisition Coupled to Visible Laser-Induced Dissociation at 473 nm (DIA-LID) for Peptide-Centric Specific Analysis of Cysteine-Containing Peptide Subset. Analytical Chemistry, American Chemical Society, 2018, 90 (6), pp.3928 - 3935. ⟨10.1021/acs.analchem.7b04821⟩. ⟨hal-01767310⟩
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Mohammad Halim, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, Philippe Dugourd, et al.. Ultraviolet, Infrared, and High-Low Energy Photodissociation of Post-Translationally Modified Peptides. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2018, 29 (2), pp.270-283. ⟨10.1007/s13361-017-1794-9⟩. ⟨hal-02303961⟩
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Mohammad Halim, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, Philippe Dugourd, et al.. Ultraviolet, Infrared, and High-Low Energy Photodissociation of Post-Translationally Modified Peptides. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2018, 29 (2), pp.270 - 283. ⟨10.1007/s13361-017-1794-9⟩. ⟨hal-01767664⟩
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2017

Journal articles

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Lény Garcia, Jérôme Lemoine, Philippe Dugourd, Marion Girod. Fragmentation patterns of chromophore-tagged peptides in visible laser induced dissociation. Rapid Communications in Mass Spectrometry, Wiley, 2017, 31 (23), pp.1985 - 1992. ⟨10.1002/rcm.7984⟩. ⟨hal-01646160⟩
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Piia Liigand, Agnes Heering, Karl Kaupmees, Ivo Leito, Marion Girod, et al.. The Evolution of Electrospray Generated Droplets is Not Affected by Ionization Mode. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2017, 28 (10), pp.2124 - 2131. ⟨10.1007/s13361-017-1737-5⟩. ⟨hal-01598111⟩
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Piia Liigand, Karl Kaupmees, Kristjan Haav, Jaanus Liigand, Ivo Leito, et al.. Think Negative: Finding the Best Electrospray Ionization/MS Mode for Your Analyte. Analytical Chemistry, American Chemical Society, 2017, 89 (11), pp.5665-5668. ⟨10.1021/acs.analchem.7b00096⟩. ⟨hal-01546359⟩
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Antonin Soleilhac, Franck Bertorelle, Philippe Dugourd, Marion Girod, Rodolphe Antoine. Monitoring methanol-induced protein unfolding by fluorescence anisotropy measurements of covalently labelled rhodamine probe. The European Physical Journal D : Atomic, molecular, optical and plasma physics, EDP Sciences, 2017, 71 (6), ⟨10.1140/epjd/e2017-70760-3⟩. ⟨hal-01569441⟩
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2016

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S Daly, Marion Girod, M Vojkovic, A Giuliani, R Antoine, et al.. Single-Photon, Double Photodetachment of Nickel Phthalocyanine Tetrasulfonic Acid 4-Anions. Journal of Physical Chemistry Letters, American Chemical Society, 2016, 7 (13), pp.2586-2590. ⟨10.1021/acs.jpclett.6b01030⟩. ⟨hal-01344589⟩
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https://hal.archives-ouvertes.fr/hal-01344589/file/NiPC.pdf BibTex
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Athanasios Zavras, George N. Khairallah, Marjan Krstić, Marion Girod, Steven Daly, et al.. Ligand-induced substrate steering and reshaping of [Ag-2(H)](+) scaffold for selective CO2 extrusion from formic acid. Nature Communications, Nature Publishing Group, 2016, 7, pp. Article Number: 11746 ⟨10.1038/ncomms11746⟩. ⟨hal-01356285⟩
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Antonin Soleilhac, Marion Girod, Philippe Dugourd, Béatrice Burdin, Julien Parvole, et al.. Temperature Response of Rhodamine B-Doped Latex Particles. From Solution to Single Particles. Langmuir, American Chemical Society, 2016, 32 (16), pp.4052-4058. ⟨10.1021/acs.langmuir.6b00647⟩. ⟨hal-01356205⟩
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Mohammad A Halim, Marion Girod, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, et al.. 213 nm Ultraviolet Photodissociation on Peptide Anions: Radical-Directed Fragmentation Patterns. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2016, 27 (3), pp.474-486. ⟨10.1007/s13361-015-1297-5⟩. ⟨hal-01356287⟩
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Mohammad A Halim, Marion Girod, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, et al.. Combined Infrared Multiphoton Dissociation with Ultraviolet Photodissociation for Ubiquitin Characterization. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2016, 27 (9), pp.1435-1442. ⟨10.1007/s13361-016-1419-8⟩. ⟨hal-01344631⟩
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https://hal.archives-ouvertes.fr/hal-01344631/file/Manuscript-HiLoPD-Halim.pdf BibTex

2015

Journal articles

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Jaanus Liigand, Anneli Kruve, Piia Liigand, Asko Laaniste, Marion Girod, et al.. Transferability of the electrospray ionization efficiency scale between different instruments. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2015, 26 (11), pp.1923-1930. ⟨10.1007/s13361-015-1219-6⟩. ⟨hal-01229075⟩
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Marion Girod, Zeljka Sanader, Marin Vojkovic, Rodolphe Antoine, Luke Macaleese, et al.. UV Photodissociation of proline-containing peptide ions: insights from molecular dynamics. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2015, 26 (3), pp.432-443. ⟨10.1007/s13361-014-1038-1⟩. ⟨hal-01187318⟩
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Antonin Soleilhac, Xavier Dagany, Philippe Dugourd, Marion Girod, Rodolphe Antoine. Correlating droplet size with temperature changes in electrospray source by optical methods.. Analytical Chemistry, American Chemical Society, 2015, 87 (16), pp.8210-8217. ⟨10.1021/acs.analchem.5b00976⟩. ⟨hal-01344760⟩
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https://hal.archives-ouvertes.fr/hal-01344760/file/ESI%20Temperature.pdf https://hal.archives-ouvertes.fr/hal-01344760/file/ESI%20Temperature%20SI.pdf BibTex
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Mohammad A Halim, Marion Girod, Luke Macaleese, Jérôme Lemoine, Rodolphe Antoine, et al.. 213 nm Ultraviolet Photodissociation on Peptide Anions: Radical-Directed Fragmentation Patterns. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2015, ⟨10.1007/s13361-015-1297-5⟩. ⟨hal-01344628⟩
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https://hal.archives-ouvertes.fr/hal-01344628/file/Manuscript-213nmUVPD-Halim%20%282%29.pdf BibTex

2014

Journal articles

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Marion Girod, Marjan Krstić, Rodolphe Antoine, Luke Macaleese, Jérôme Lemoine, et al.. Formation and characterisation of the silver hydride nanocluster cation [Ag3H2((Ph2P)(2)CH2)](+) and its release of hydrogen. Chemistry - A European Journal, Wiley-VCH Verlag, 2014, 20 (50), pp.16626-16633. ⟨10.1002/chem.201404110⟩. ⟨hal-01230129⟩
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Jaanus Liigand, Anneli Kruve, Ivo Leito, Marion Girod, Rodolphe Antoine. Effect of mobile phase on electrospray ionization efficiency. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2014, 25 (11), pp.1853-1861. ⟨10.1007/s13361-014-0969-x⟩. ⟨hal-01230362⟩
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Alexander Chramow, Tanam S Hamid, Livia S Eberlin, Marion Girod, Demian R Ifa. Imaging of whole zebra fish (Danio rerio) by desorption electrospray ionization mass spectrometry.. Rapid Communications in Mass Spectrometry, Wiley, 2014, 28 (19), pp.2084-2088. ⟨10.1002/rcm.6993⟩. ⟨hal-01070832⟩
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Quentin Enjalbert, Marion Girod, Jérémy Jeudy, Jordane Biarc, Romain Simon, et al.. Combined collision-induced dissociation and photo-selected reaction monitoring mass spectrometry modes for simultaneous analysis of coagulation factors and estrogens. Journal of Pharmaceutical Analysis, Elsevier B.V. on behalf of Xi'an Jiaotong University, 2014, 4 (3), pp.183-189. ⟨10.1016/j.jpha.2013.09.004⟩. ⟨hal-01356364⟩
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Marion Girod, Jordane Biarc, Quentin Enjalbert, Arnaud Salvador, Rodolphe Antoine, et al.. Implementing visible 473 nm photodissociation in a Q-Exactive mass spectrometer: towards specific detection of cysteine-containing peptides. The Analyst, JSTOR, 2014, 139 (21), pp.5523-5530. ⟨10.1039/C4AN00956H⟩. ⟨hal-01345989⟩
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https://hal.archives-ouvertes.fr/hal-01345989/file/LIDQexvs.pdf https://hal.archives-ouvertes.fr/hal-01345989/file/Supplementary%20information_Qex.pdf BibTex
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Marion Girod, Quentin Enjalbert, Claire Brunet, Rodolphe Antoine, Jérôme Lemoine, et al.. Structural basis of protein oxidation resistance: a lysozyme study.. PLoS ONE, Public Library of Science, 2014, 9 (7), pp.e101642. ⟨10.1371/journal.pone.0101642⟩. ⟨hal-01071810⟩
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Marion Girod, Zeljka Sanader, Marin Vojkovic, Rodolphe Antoine, Luke Macaleese, et al.. UV Photo-dissociation of proline-containing peptide ions: Insights from molecular dynamics. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2014, ⟨10.1007/s13361-014-1038-1⟩. ⟨hal-01345987⟩
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https://hal.archives-ouvertes.fr/hal-01345987/file/peptPro.pdf https://hal.archives-ouvertes.fr/hal-01345987/file/Supporting%20material%20peptPro.pdf BibTex

2013

Journal articles

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Quentin Enjalbert, Marion Girod, Romain Simon, Jéremy Jeudy, Fabien Chirot, et al.. Improved detection specificity for plasma proteins by targeting cysteine-containing peptides with photo-SRM. Analytical and Bioanalytical Chemistry, Springer Verlag, 2013, 405 (7), pp.2321-2331. ⟨10.1007/s00216-012-6603-5⟩. ⟨hal-00875276⟩
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Marion Girod, Rodolphe Antoine, Jérôme Lemoine, Philippe Dugourd, Laurence Charles. Structural characterization of a poly(methacrylicacid)/poly(methylmethacrylate) copolymer by activated electron photo-detachment dissociation. International Journal of Mass Spectrometry, Elsevier, 2013, 333, pp.27-33. ⟨10.1016/j.ijms.2012.08.018⟩. ⟨hal-00875704⟩
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2012

Journal articles

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Romain Simon, Marion Girod, Catherine Fonbonne, Arnaud Salvador, Yohann Clément, et al.. Total ApoE and ApoE4 isoform assays in an alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides. Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2012, 11 (11), pp.1389-1403. ⟨10.1074/mcp.M112.018861⟩. ⟨hal-00875286⟩
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Isabelle Chaduc, Marion Girod, Rodolphe Antoine, Bernadette Charleux, Franck d'Agosto, et al.. Batch emulsion polymerization mediated by poly(methacrylic acid) macroRAFT agents: one-pot synthesis of self-stabilized particles. Macromolecules, American Chemical Society, 2012, 45 (15), pp.5881-5893. ⟨10.1021/ma300875y⟩. ⟨hal-00955084⟩
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Marion Girod, Claire Brunet, Rodolphe Antoine, Jérôme Lemoine, Philippe Dugourd, et al.. Efficient structural characterization of poly(methacrylic acid) by activated-electron photodetachment dissociation.. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2012, 23 (1), pp.7-11. ⟨10.1007/s13361-011-0279-5⟩. ⟨hal-00875927⟩
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2011

Journal articles

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Marion Girod, Rodolphe Antoine, Jérôme Lemoine, Philippe Dugourd, Laurence Charles. End-group characterization of poly(styrene sulfonate sodium salt) by activated electron photo-detachment dissociation.. Rapid Communications in Mass Spectrometry, Wiley, 2011, 25 (21), pp.3259-3266. ⟨10.1002/rcm.5228⟩. ⟨hal-00875937⟩
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Publications not affiliated to the Institute for Analytical Science (ISA UMR 5280)

2012
Marion Girod, Rodolphe Antoine, Philippe Dugourd, Alex Mordehai, Craig Love, Stafford. Basic Vapor Exposure for Tuning the Charge State Distribution of Proteins in Negative Electrospray Ionization: Elucidation of Mechanisms by Fluorescence Spectroscopy. Journal of The American Society for Mass Spectrometry, Springer Verlag (Germany), 2012, 23 (7), pp.1221-1231.

Marion Girod, Xavier Dagany, Veronique Boutou, Michel Broyer, Rodolphe Antoine, et al.. Profiling an electrospray plume by laser-induced fluorescence and Fraunhofer diffraction combined to mass spectrometry: influence of size and composition of droplets on charge-state distributions of electrosprayed proteins. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2012, 14 (26), pp.9389. 〈10.1039/c2cp23341j〉

2011
Marion Girod, Xavier Dagagny, Rodolphe Antoine and Philippe Dugourd. Relation between charge state distributions of peptide anions and pH changes in the electrospray plume. A mass spectrometry and optical spectroscopy investigation. International Journal of Mass Spectrometry, 2011, 308 (1), pp.41-48

Marion Girod, Encarnacion Moyano, Dahlia Campbell and R. Graham Cooks. Accelerated Bimolecular Reactions in Microdroplets Studied by Desorption Electrospray Ionization Mass Spectrometry. Chemical Science, 2011, 2 (3), pp.501-510.

Marion Girod, Yunzhou Shi, Ji-Xin Cheng and R. Graham Cooks. Mapping Lipid Alterations in Traumatically Injured Rat Spinal Cord by Desorption Electrospray Ionization Imaging Mass Spectrometry. Analytical Chemistry, 2011, 83 (1), pp.207–215.