Alain BERTHOD

Emeritus CNRS Research Director
work phone: 0437423553

Research

Mostly interested in the separation of enantiomers by any technique: gas or liquid chromatography, or electrophoresis focussing on new chiral selectors and variation in the mobile phase (ionic liquids).
He still follows the developments in the liquid chromatography methods using two liquid phases and either called countercurrent chromatography or centrifugal partition chromatography.

Biography

Dr Berthod taught for five years in French high schools with the title of Professeur agrégé (chemistry). Recruited by the National Center for Scientific Research (CNRS) after getting his PhD at the University of Lyon 1 (1979) in electrochemistry (advisor: Dr Mylène Bréant), he made a career in this French governmental institution reaching the highest DR1 level in 2011.
He successively developed the techniques of micellar liquid chromatography and countercurrent chromatography authoring 8 books, more than 200 research articles, 40 book chapters and presenting more than 250 oral or poster communications in international conferences. (ORCID Researcher ID: 0000 0002 7452 9527)
He was invited as visiting scientist by the University of Florida (Pr. James Winefordner, 1986-1987, spectroscopy), the University of Missouri-Rolla (Pr. Daniel Armstrong, 1995, macrocyclic glycopeptides), Florida State University (Pr. John Dorsey, 2000, separation mechanisms), Iowa State University (Pr. Daniel Armstrong, 2001-2002, ionic liquids) and since 2006 University of Texas at Arlington in summer stays invited by Pr. Armstrong to work on chiral separations.
Since 2007, he is editor in chief of the journal “Separation & Purification Reviews” (Taylor & Francis, Philadelphia, USA).
He was granted the Emeritus status in 2015.

Keywords

Separation, countercurrent chromatography, solvents, chiral separations, ionic liquids.

Publications

Articles in peer-review journals since 2011

Publications HAL de Alain,Berthod

2019

Journal articles

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Lucile Lecas, Jérôme Randon, Alain Berthod, Vincent Dugas, Claire Demesmay. Monolith weak affinity chromatography for μg-protein-ligand interaction study. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2019, 166, pp.164-173. ⟨hal-02015987⟩
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2018

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Mohsen Talebi, Rahul Patil, Leonard Sidisky, Alain Berthod, Daniel Armstrong. Variation of anionic moieties of dicationic ionic liquid GC stationary phases: Effect on stability and selectivity. Analytica Chimica Acta, Elsevier Masson, 2018, 1042, pp.155-164. ⟨10.1016/j.aca.2018.07.047⟩. ⟨hal-01933471⟩
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Rahul Patil, Mohsen Talebi, Leonard Sidisky, Alain Berthod, Daniel Armstrong. Gas chromatography selectivity of new phosphonium-based dicationic ionic liquid stationary phases. Journal of Separation Science, Wiley-VCH Verlag, 2018, 41 (22), pp.4142-4148. ⟨10.1002/jssc.201800695⟩. ⟨hal-02016014⟩
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Hongyue Guo, M. Farooq Wahab, Alain Berthod, Daniel Armstrong. Mass spectrometry detection of basic drugs in fast chiral analyses with vancomycin stationary phases. Journal of Pharmaceutical Analysis, Elsevier B.V. on behalf of Xi'an Jiaotong University, 2018, 8 (5), pp.324-332. ⟨10.1016/j.jpha.2018.08.001⟩. ⟨hal-01936927⟩
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Garrett Hellinghausen, Diego A. Lopez, Jauh Lee, Yadi Wang, Choyce Weatherly, et al.. Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase. Chirality, Wiley, 2018, 30 (9), pp.1067-1078. ⟨10.1002/chir.22985⟩. ⟨hal-02016053⟩
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Rahul A Patil, Mohsen Talebi, Alain Berthod, Daniel W Armstrong. Dicationic ionic liquid thermal decomposition pathways. Analytical and Bioanalytical Chemistry, Springer Verlag, 2018, 410 (19), pp.4645-4655. ⟨10.1007/s00216-018-0878-0⟩. ⟨hal-01858978⟩
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Mohsen Talebi, Rahul A Patil, Leonard Sidisky, Alain Berthod, Daniel W Armstrong. Branched-chain dicationic ionic liquids for fatty acid methyl ester assessment by gas chromatography. Analytical and Bioanalytical Chemistry, Springer Verlag, 2018, 410 (19), pp.4633-4643. ⟨10.1007/s00216-017-0722-y⟩. ⟨hal-01858986⟩
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Alain Berthod, M.J. Ruiz-Ángel, S. Carda-Broch. Recent advances on ionic liquid uses in separation techniques. Journal of Chromatography A, Elsevier, 2018, 1559, pp.2-16. ⟨10.1016/j.chroma.2017.09.044⟩. ⟨hal-01825252⟩
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2017

Journal articles

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Alain Berthod. Separation and Purification with a Liquid Stationary Phase. Separations, MDPI, 2017, 4 (4), pp.article number: 30. ⟨10.3390/separations4040030⟩. ⟨hal-01687013⟩
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Darshan Patel, Ross M. Woods, Zachary S. Breitbach, Alain Berthod, Daniel W. Armstrong. Thermal racemization of biaryl atropisomers. Tetrahedron: Asymmetry, Elsevier, 2017, 28 (11), pp.1557 - 1561. ⟨10.1016/j.tetasy.2017.09.006⟩. ⟨hal-01682292⟩
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2016

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Yeeun Lim, Zachary S. Breitbach, Daniel W. Armstrong, Alain Berthod. Screening primary racemic amines for enantioseparation by derivatized polysaccharide and cyclofructan columns. Journal of Pharmaceutical Analysis, Elsevier B.V. on behalf of Xi'an Jiaotong University, 2016, 6 (6), pp.345-355. ⟨10.1016/j.jpha.2016.07.003⟩. ⟨hal-01546508⟩
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Norbert Fumat, Alain Berthod, Karine Faure. Effect of operating parameters on a centrifugal partition chromatography separation . Chinese Journal of Chromatography, Elsevier, 2016, 1474, pp.47-58 ⟨10.1016/j.chroma.2016.10.014⟩. ⟨hal-01515264⟩
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Elodie Bouju, Alain Berthod, Karine Faure. Carnosol purification. Scaling-up centrifugal partition chromatography separations. Journal of Chromatography A, Elsevier, 2016, 1466, pp.59-66 ⟨10.1016/j.chroma.2016.08.015⟩. ⟨hal-01515260⟩
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Zachary Breitbach, Alain Berthod, Ke Huang, Daniel Armstrong. Mass spectrometric detection of trace anions: The evolution of paired-ion electrospray ionization (PIESI). Mass Spectrometry Reviews, Wiley, 2016, 35 (2), pp.201-218. ⟨10.1002/mas.21448⟩. ⟨hal-02016086⟩
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A. Adekenov, P. Y. Sakenova, A. Ivasenko, A. Khabarov, S. M. Adekenov, et al.. Gram-Scale Purification of Two Sesquiterpene Lactones from Chartolepsis Intermedia Boiss.. Chromatographia, Springer Verlag, 2016, 79 (1-2), pp.37-43. ⟨10.1007/s10337-015-3000-1⟩. ⟨hal-01546502⟩
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Muhammad Khan, Zachary S Breitbach, Alain Berthod, Daniel W. Armstrong. Chlorinated aromatic derivatives of cyclofructan 6 as HPLC chiral stationary phases. Journal of Liquid Chromatography and Related Technologies, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2016, 39 (10), pp.497-503. ⟨10.1080/10826076.2016.1196217⟩. ⟨hal-01546507⟩
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Lillian A. Frink, Alain Berthod, Qing-Long Xu, Hongyin Gao, Laszlo Kurti, et al.. Separation of 2-naphthol atropisomers on cyclofructan-based chiral stationary phases. Journal of Liquid Chromatography and Related Technologies, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2016, 39 (15), pp.710-717. ⟨10.1080/10826076.2016.1234395⟩. ⟨hal-01546506⟩
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2015

Journal articles

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Yun-Cheol Na, Alain Berthod, Daniel Armstrong. Cation-enhanced capillary electrophoresis separation of atropoisomer anions. Electrophoresis, Wiley-VCH Verlag, 2015, 36 (23), pp.2859-2865. ⟨10.1002/elps.201500292⟩. ⟨hal-02016106⟩
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M. Farooq Wahab, Zachary S Breitbach, Daniel W. Armstrong, Rick Strattan, Alain Berthod. Problems and pitfalls in the analysis of amygdalin and its epimer. Journal of Agricultural and Food Chemistry, American Chemical Society, 2015, 63 (40), pp.8966-8973. ⟨10.1021/acs.jafc.5b03120⟩. ⟨hal-01229264⟩
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M. C. García-Alvarez-Coque, Maria Jose Ruiz-Angel, Alain Berthod, Samuel Carda-Broch. On the use of ionic liquids as mobile phase additives in high-performance liquid chromatography. A review. Analytica Chimica Acta, Elsevier Masson, 2015, 883, pp.1-21. ⟨10.1016/j.aca.2015.03.042⟩. ⟨hal-01229948⟩
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Elodie Bouju, Alain Berthod, Karine Faure. Scale-up in centrifugal partition chromatography: The “free-space between peaks” method. Journal of Chromatography A, Elsevier, 2015, 1409, pp.70-78. ⟨10.1016/j.chroma.2015.07.020⟩. ⟨hal-01186354⟩
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Alain Berthod, Karine Faure. Revisiting resolution in hydrodynamic countercurrent chromatography: Tubing bore effect. Journal of Chromatography A, Elsevier, 2015, 1390, pp.71-77. ⟨10.1016/j.chroma.2015.02.053⟩. ⟨hal-01164863⟩
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Nilusha L. Padivitage, Jonathan P. Smuts, Zachary S Breitbach, Daniel W. Armstrong, Alain Berthod. Preparation and Evaluation of HPLC Chiral Stationary Phases Based on Cationic/Basic Derivatives of Cyclofructan 6. Journal of Liquid Chromatography and Related Technologies, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2015, 38 (5), pp.550-560. ⟨10.1080/10826076.2014.917668⟩. ⟨hal-01119582⟩
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2014

Journal articles

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Emilie Chorier, Nicolas Blanc, Jean-Claude Cannot, Alain Berthod. Headspace GC-MS for the determination of halogenated hydrocarbons, ethers and aromatic volatiles in fabric and leather. Journal of the american leather chemists association, 2014, 109 (10), pp.322-329. ⟨hal-01077199⟩
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Karine Faure, Elodie Bouju, J. Doby, Alain Berthod. Limonene in Arizona liquid systems used in countercurrent chromatography. II Polarity and stationary-phase retention. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (24), pp.5919-5926. ⟨10.1007/s00216-014-8030-2⟩. ⟨hal-01073273⟩
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Karine Faure, Elodie Bouju, Pauline Suchet, Alain Berthod. Limonene in Arizona liquid systems used in countercurrent chromatography. I Physicochemical properties.. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (24), pp.5909-5917. ⟨10.1007/s00216-014-8005-3⟩. ⟨hal-01073271⟩
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M. J. Ruiz-Angel, M. C. García-Alvarez-Coque, Alain Berthod, S. Carda-Broch. Are analysts doing method validation in liquid chromatography?. Journal of Chromatography A, Elsevier, 2014, 1353, pp.2-9. ⟨10.1016/j.chroma.2014.05.052⟩. ⟨hal-01071824⟩
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Zachary S Breitbach, Choyce A Weatherly, Ross M Woods, Chengdong Xu, Glenda Vale, et al.. Development and evaluation of gas and liquid chromatographic methods for the analysis of fatty amines.. Journal of Separation Science, Wiley-VCH Verlag, 2014, 37 (5), pp.558-565. ⟨10.1002/jssc.201301265⟩. ⟨hal-00971762⟩
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2013

Journal articles

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Karine Faure, Elodie Bouju, Pauline Suchet, Alain Berthod. Use of limonene in countercurrent chromatography: a green alkane substitute.. Analytical Chemistry, American Chemical Society, 2013, 85 (9), pp.4644-4650. ⟨10.1021/ac4002854⟩. ⟨hal-00876113⟩
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Karine Faure, Nazim Mekaoui, Jérémy Meucci, Alain Berthod. Solvent selection in countercurrent chromatography using small-volume hydrostatic columns. LCGC North America, Advanstar Communications Inc, 2013, 31 (2), pp.132-143. ⟨hal-00859788⟩
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Haixiao Qiu, Daniel Armstrong, Alain Berthod. Thermodynamic studies of a zwitterionic stationary phase in hydrophilic interaction liquid chromatography. Journal of Chromatography A, Elsevier, 2013, 1272, pp.81-89. ⟨10.1016/j.chroma.2012.11.071⟩. ⟨hal-02016325⟩
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Shihua Wu, Junling Liang, Alain Berthod. Comparing two models of gradient elution in counter-current chromatography.. Journal of Chromatography A, Elsevier, 2013, 1274, pp.77-81. ⟨10.1016/j.chroma.2012.11.078⟩. ⟨hal-00877220⟩
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2012

Journal articles

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Nazim Mekaoui, Karine Faure, Alain Berthod. Advances in countercurrent chromatography for protein separations. Bioanalysis, 2012, 4 (7), pp.833-844. ⟨10.4155/BIO.12.27⟩. ⟨hal-00799824⟩
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Sirantha Perera, Alain Berthod, Edra Dodbiba, Daniel W Armstrong. Coupling solid-phase microextraction and laser desorption ionization for rapid identification of biological material.. Rapid Communications in Mass Spectrometry, Wiley, 2012, 26 (7), pp.853-862. ⟨10.1002/rcm.6168⟩. ⟨hal-00877227⟩
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Shihua Wu, Dingfang Wu, Junling Liang, Alain Berthod. Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.. Journal of Separation Science, Wiley-VCH Verlag, 2012, 35 (8), pp.964-976. ⟨10.1002/jssc.201100993⟩. ⟨hal-00877231⟩
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Samuel Carda-Broch, Josep Esteve-Romero, Maria Rambla-Alegre, Maria Jose Ruiz-Angel, Alain Berthod, et al.. Micellar liquid chromatography: recent advances and applications. Chromatography research international, 2012, 2012, pp.Article ID 573690. ⟨10.1155/2012/573690⟩. ⟨hal-00982973⟩
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2011

Journal articles

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A. Rey, N. Blanc, J.-C. Cannot, Alain Berthod. Determination of short polychlorinated alkanes in leather using gas chromatography-electron capture negative chemical ionisation mass spectrometry. Journal of the american leather chemists association, 2011, 106 (10), pp.294-302. ⟨hal-00913809⟩
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Alain Berthod. Special Issue Honoring Carel J. van Oss: A Lifetime Devoted to Scientific Advancement - Foreword. Separation and Purification Reviews, Taylor & Francis, 2011, 40 (3), pp.161-162. ⟨10.1080/15422119.2011.555207⟩. ⟨hal-00877239⟩
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Direction of books or issues of journals – books – book chapters – Proceedings

Publications HAL de Alain,Berthod

2015

Book sections

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Alain Berthod, Karine Faure. Solvents in chromatography and electrophoresis. Anderson J. L., Berthod A., Pino Estévez V., Stalcup A. M. Analytical Separation Science, 1, Wiley-VCH Verlag GmbH & Co. KGaA., pp.135-158, 2015, 9783527678129. ⟨10.1002/9783527678129.assep007⟩. ⟨hal-01356733⟩
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Alain Berthod, Karine Faure. Separations with a Liquid Stationary Phase: Countercurrent Chromatography or Centrifugal Partition Chromatography. Anderson J. L., Berthod A., Pino Estévez V., Stalcup A. M. Analytical Separation Science, 4, Wiley-VCH Verlag GmbH & Co. KGaA., pp.1177-1206, 2015, 9783527678129. ⟨10.1002/9783527678129.assep046⟩. ⟨hal-01255453⟩
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Pascal Cardinaël, Hervé Casabianca, Valérie Agasse-Peulon, Alain Berthod. Sample Derivatization in Separation Science. J. Anderson; A. Berthod; V. Pino; A. M. Stalcup. Analytical Separation Science, Wiley-VCH, pp.1725 - 1756, 2015, ⟨10.1002/9783527678129.assep063⟩. ⟨hal-01936976⟩
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Directions of work or proceedings

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Jared Anderson, Alain Berthod, Verónica Pino Estévez, Apryll Stalcup. Analytical Separation Science. France. Wiley-VCH Verlag GmbH & Co. KGaA., pp.5 volumes, 2015, 9783527678129. ⟨10.1002/9783527678129⟩. ⟨hal-01356736⟩
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2014

Book sections

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Karine Faure, Nazim Mekaoui, Alain Berthod. Saving solvents in chromatographic purifications: the counter-current chromatography technique. Inamuddin, D., Mohammad, A. (Eds.). Green chromatographic techniques. Separation and purification of organic and inorganic analytes, Springer, pp.1-18, 2014, 978-94-007-7734-7. ⟨hal-00983090⟩
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Alain Berthod. Comments on “Counter-current motion in counter-current chromatography” by Yoichiro Ito. 8th International Conference on Countercurrent Chromatography – CCC 2014, Jul 2014, Uxbridge, United Kingdom. 1372, pp.260-261, 2014, ⟨10.1016/j.chroma.2014.10.103⟩. ⟨hal-01230114⟩
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2012

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Alain Berthod. Chromatographic separations and analysis: Macrocyclic glycopeptide chiral stationary phases. Carreira Erick M. and Yamamoto Hisashi. Comprehensive chirality, Elsevier, 39 p, 2012, 978-0-08-095167-6. ⟨hal-00982999⟩
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Nazim Mekaoui, Joseph Chamieh, Vincent Dugas, Claire Demesmay, Alain Berthod. Purification of Coomassie Brilliant Blue G-250 by multiple dual mode countercurrent chromatography.. 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques (HPLC), Jun 2011, Budapest, Hungary. 1232, pp.134-141, 2012, ⟨10.1016/j.chroma.2011.11.022⟩. ⟨hal-00704027⟩
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2011

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Nazim Mekaoui, Alain Berthod. Using the liquid nature of the stationary phase. VI. Theoretical study of multi-dual mode countercurrent chromatography. 6th International Conference on Countercurrent Chromatography (CCC 2010), Jul 2010, Lyon, France. Journal of Chromatography A, 1218 (36), pp.6061-6071, 2011, ⟨10.1016/j.chroma.2010.12.104⟩. ⟨hal-00973498⟩
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Alain Berthod, Nazim Mekaoui. Distribution ratio, distribution constant and partition coefficient. Countercurrent chromatography retention of benzoic acid.. 6th International Conference on Countercurrent Chromatography (CCC 2010), Jul 2010, Lyon, France. Journal of Chromatography A, 1218 (36), pp.6024-6030, 2011, ⟨10.1016/j.chroma.2010.12.027⟩. ⟨hal-00973451⟩
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Alain Berthod. Selected papers from the 6th international conference on countercurrent chromatography Lyon France, 28-30 July 2010 - Foreword. Journal of Chromatography A, 1218 (36), pp.6005-6008, 2011, ⟨10.1016/j.chroma.2010.11.064⟩. ⟨hal-02016356⟩
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M. J. Ruiz-Angel, S. Carda-Broch, Amélie Levet, Alain Berthod. Hydrophobicity of ionisable compounds studied by countercurrent chromatography. 6th International Conference on Countercurrent Chromatography (CCC 2010), Jul 2010, Lyon, France. Journal of Chromatography A, 1218 (36), pp.6044-6052, 2011, ⟨10.1016/j.chroma.2010.12.027⟩. ⟨hal-00973468⟩
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