
Florence LAGARDE
Contact
Research
- Elaboration of innovative strategies for the robust and efficient immobilization of enzymes, antibodies or bacterial cells onto electroactive surfaces
- Investigation and optimization of interaction mechanisms at the electrode/biomaterial/solution interfaces
- Application to the development of highly sensitive and selective electrochemical biosensors for environmental, food and health applications
Biography
Florence Lagarde is research scientist at the Centre National de la Recherche Scientifique (CNRS), France, since 1991. She graduated from the Ecole Nationale Supérieure des Industries Chimiques, Nancy, and obtained a M.Sc. in chemical engineering in 1987. She received a Ph.D. degree in polymer physical chemistry from the University of Strasbourg in 1991. She started her career at the Laboratory of Inorganic and Analytical Chemistry of Strasbourg University, working on the development of analytical methods for inorganic analysis and speciation and their application to the study of trace metals behaviour in the environment. In 2004, she joined the Institute of Analytical Sciences, Lyon University. She currently develops innovative strategies for the robust and efficient immobilization of biomolecules or biomimics onto electroactive surfaces in view of the development of electrochemical biosensors for environmental, food and health applications. She has been involved in the supervision or co- supervision of 15 phD students, as well as in several research projects with industrial and academic partners. She is the author of more than 80 publications and 100 communications in national and international conferences.
Publications
2020
Journal articles
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- Florence Lagarde. José Manuel Díaz-Cruz, Miquel Esteban, Cristina Ariño: Chemometrics in electroanalysis. Analytical and Bioanalytical Chemistry, Springer Verlag, 2020, 412, pp.3017-3018. ⟨10.1007/s00216-020-02522-x⟩. ⟨hal-02512058⟩
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- Eleni Sapountzi, Jean-François Chateaux, Florence Lagarde. Combining Electrospinning and Vapor-Phase Polymerization for the Production of Polyacrylonitrile/ Polypyrrole Core-Shell Nanofibers and Glucose Biosensor Application. Frontiers in Chemistry, Frontiers, 2020, 8, pp.678. ⟨10.3389/fchem.2020.00678⟩. ⟨hal-02984012⟩
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2018
Journal articles
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- Amina Betatache, Florence Lagarde, Nicole Jaffrezic-Renault. Optimization of the surface initiated polymerization of molecular imprinted methacrylate polymer on gold electrode for the detection of testosterone. Journal of New Technology and Materials, Université Larbi Ben Mhidi de Oum El Bouaghi, 2018, 8 (2), pp.10-15. ⟨hal-02115862⟩
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- Narjes Kolahchi, Mohamed Braiek, Gholamhossein Ebrahimipour, Seyed Omid Ranaei-Siadat, Florence Lagarde, et al.. Direct detection of phenol using a new bacterial strain-based conductometric biosensor. Journal of Environmental Chemical Engineering, Elsevier, 2018, 6 (1), pp.478-484. ⟨10.1016/j.jece.2017.12.023⟩. ⟨hal-02116197⟩
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- Estelle Lebègue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Responsive Polydiacetylene Vesicles for Biosensing Microorganisms. Sensors, MDPI, 2018, 18 (2), pp.599. ⟨10.3390/s18020599⟩. ⟨hal-01740158⟩
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- Estelle Lebegue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Biomimetic vesicles for electrochemical sensing. Current Opinion in Electrochemistry, Elsevier, 2018, 12 (12), pp.101-106. ⟨10.1016/j.coelec.2018.06.005⟩. ⟨hal-01928207⟩
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2017
Journal articles
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- Hana Fourou, Mohamed Braiek, Anne Bonhommé, Florence Lagarde, Ali Zazoua, et al.. Voltammetric Sensor Based on a Double-Layered Molecularly Imprinted Polymer for Testosterone. Analytical Letters, Taylor & Francis, 2017, 51 (3), pp.312-322. ⟨10.1080/00032719.2017.1298118⟩. ⟨hal-02116237⟩
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- Oleksandr O Soldatkin, K. V. Stepurska, V. M. Arkhypova, A.P. Soldatkin, A. V. El'Skaya, et al.. Conductometric enzyme biosensor for patulin determination. Sensors and Actuators B: Chemical, Elsevier, 2017, 239, pp.1010-1015. ⟨10.1016/j.snb.2016.08.121⟩. ⟨hal-01519020⟩
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- Eleni Sapountzi, Mohamed Braiek, Francis Vocanson, Jean-François Chateaux, Nicole Jaffrezic-Renault, et al.. Gold nanoparticles assembly on electrospun poly(vinylalcohol) /poly(ethyleneimine)/glucose oxidase nanofibers for ultrasensitive electrochemical glucose biosensing . Sensors and Actuators B: Chemical, Elsevier, 2017, 238, pp.392-401. ⟨10.1016/j.snb.2016.07.062⟩. ⟨ujm-01514982⟩
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- Eleni Sapountzi, Mohamed Braiek, Jean-François Chateaux, Nicole Jaffrezic-Renault, Florence Lagarde. Recent Advances in Electrospun Nanofiber Interfaces for Biosensing Devices. Sensors, MDPI, 2017, 17 (8), pp.1887. ⟨10.3390/s17081887⟩. ⟨hal-01579587⟩
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2016
Journal articles
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- Lucian Rotariu, Florence Lagarde, Nicole Jaffrezic-Renault, Camelia Bala. Electrochemical biosensors for fast detection of food contaminants trends and perspective. Trends in Analytical Chemistry, Elsevier, 2016, 79, pp.80-87. ⟨10.1016/j.trac.2015.12.017⟩. ⟨hal-01363674⟩
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- C. Maddi, Florent Bourquard, T Tite, A.-S. Loir, C. Donnet, et al.. Structure, electrochemical properties and functionalization of amorphous CN films deposited by femtosecond pulsed laser ablation. Diamond and Related Materials, Elsevier, 2016, DIAMOND AND RELATED MATERIALS, 65, pp.17-25. ⟨10.1016/j.diamond.2016.01.001⟩. ⟨hal-01363692⟩
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- Ivan S Kucherenko, D. Yu. Kucherenko, Oleksandr O Soldatkin, Florence Lagarde, S.V. Dzyadevych, et al.. A novel conductometric biosensor based on hexokinase for determination of adenosine triphosphate. Talanta, Elsevier, 2016, 150, pp.469-475 ⟨10.1016/j.talanta.2015.12.069⟩. ⟨hal-01363675⟩
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- Philippe Fortgang, Teddy Tite, Vincent Barnier, Nedjla Zehani, Chiranjeevi Maddi, et al.. Robust Electrografting on Self-Organized 3D Graphene Electrodes. ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2016, 8 (Issue : 2), pp.1424-1433. ⟨10.1021/acsami.5b10647⟩. ⟨emse-01496461⟩
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2015
Journal articles
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- Fatma Dridi, Mouna Marrakchi, Mohamed Gargouri, Alvaro Garcia-Cruz, Francis Vocanson, et al.. Thermolysin entrapped in a gold nanoparticles/polymer composite for direct and sensitive conductometric biosensing of ochratoxin A in olive oil. Sensors and Actuators B: Chemical, Elsevier, 2015, 221, pp.480-490. ⟨10.1016/j.snb.2015.06.120⟩. ⟨hal-01229058⟩
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- Ivan S Kucherenko, Oleksandr O Soldatkin, Florence Lagarde, Nicole Jaffrezic-Renault, S. V. Dzyadevych, et al.. Determination of total creatine kinase activity in blood serum using an amperometric biosensor based on glucose oxidase and hexokinase. Talanta, Elsevier, 2015, 144, pp.604-611. ⟨10.1016/j.talanta.2015.06.079⟩. ⟨hal-01234221⟩
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- K. V. Stepurska, O. O. Soldatkin, V. M. Arkhypova, A.P. Soldatkin, Florence Lagarde, et al.. Development of novel enzyme potentiometric biosensor based on pH-sensitive field-effect transistors for aflatoxin B1 analysis in real samples. Talanta, Elsevier, 2015, 144, pp.1079-1084. ⟨10.1016/j.talanta.2015.07.068⟩. ⟨hal-01230636⟩
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- Zhenzhong Guo, Nadia Zine, Florence Lagarde, Julien Daligault, Marie-Annick Persuy, et al.. A novel platform based on immobilized histidine tagged olfactory receptors, for the amperometric detection of an odorant molecule characteristic of boar taint. Food Chemistry, Elsevier, 2015, 184, pp.1-6. ⟨10.1016/j.foodchem.2015.03.066⟩. ⟨hal-01186656⟩
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- Ivan S Kucherenko, Oleksandr O Soldatkin, Berna Ozansoy Kasap, Salih Kaan Kirdeciler, Burcu Akata Kurc, et al.. Nanosized zeolites as a perspective material for conductometric biosensors creation. Nanoscale Research Letters, SpringerOpen, 2015, 10, pp.Article Number: 209 ⟨10.1186/s11671-015-0911-6⟩. ⟨hal-01363689⟩
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- Oleksandr O Soldatkin, Margaryta K. Shelyakina, Valentyna Arkhypova, Esin Soy, Salih Kaan Kirdeciler, et al.. Nano- and microsized zeolites as a perspective material for potentiometric biosensors creation. Nanoscale Research Letters, SpringerOpen, 2015, 10, pp.Article Number: 59. ⟨10.1186/s11671-015-0768-8⟩. ⟨hal-01363685⟩
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- Zhenzhong Guo, Anca Florea, Cecilia Cristea, François Bessueille, Francis Vocanson, et al.. 1,3,5-Trinitrotoluene detection by a molecularly imprinted polymer sensor based on electropolymerization of a microporous-metal-organic framework. Sensors and Actuators B: Chemical, Elsevier, 2015, 207, pp.960-966. ⟨10.1016/j.snb.2014.06.137⟩. ⟨hal-01580531⟩
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- Viktoriya M. Pyeshkova, Oleksandr Y. Dudchenko, Oleksandr O Soldatkin, Berna Ozansoy Kasap, Florence Lagarde, et al.. Application of silicalite-modified electrode for the development of sucrose biosensor with improved characteristics. Nanoscale Research Letters, SpringerOpen, 2015, 10, pp.149. ⟨10.1186/s11671-015-0853-z⟩. ⟨hal-01229965⟩
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- Fatma Dridi, Mouna Marrakchi, Mohamed Gargouri, Joëlle Saulnier, Nicole Jaffrezic-Renault, et al.. Comparison of carboxypeptidase Y and thermolysin for ochratoxin A electrochemical biosensing. Analytical Methods, Royal Society of Chemistry, 2015, 7 (20), pp.8954-8960. ⟨10.1039/c5ay01905b⟩. ⟨hal-01229276⟩
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- Eleni Sapountzi, Mohamed Braiek, Carole Farre, Madjid Arab, Jean-François Chateaux, et al.. One-Step Fabrication of Electrospun Photo-Cross-Linkable Polymer Nanofibers Incorporating Multiwall Carbon Nanotubes and Enzyme for Biosensing. Journal of The Electrochemical Society, Electrochemical Society, 2015, 162 (10), pp.B275-B281. ⟨10.1149/2.0831510jes⟩. ⟨hal-01229524⟩
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2014
Journal articles
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- Amina Betatache, Florence Lagarde, Corinne Sanglar, Anne Bonhommé, Didier Léonard, et al.. Gold electrodes modified with molecular imprinted acrylate polymer for impedimetric determination of testosterone. Sensors & Transducers Journal, International Frequency Sensor Association (IFSA), 2014, 27, pp.92-99. ⟨hal-01006335⟩
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- Thanhthuy Nguyen Boisse, Joëlle Saulnier, Nicole Jaffrezic-Renault, Florence Lagarde. Miniaturised enzymatic conductometric biosensor with Nafion membrane for the direct determination of formaldehyde in water samples.. Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (4), pp.1039-1048. ⟨10.1007/s00216-013-7197-2⟩. ⟨hal-00956244⟩
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- Nadèje Tekaya, Olga Saiapina, Hatem Ben Ouada, Florence Lagarde, Philippe Namour, et al.. Bi-Enzymatic Conductometric Biosensor for Detection of Heavy Metal Ions and Pesticides in Water Samples Based on Enzymatic Inhibition in Arthrospira platensis. Journal of Environmental Protection, Scientific Research Publishing, 2014, 5, pp.441-453. ⟨10.4236/jep.2014.55047⟩. ⟨hal-01529622⟩
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2013
Journal articles
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- Nadèje Tekaya, Ibtissèm Gammoudi, Mohamed Braiek, Hakim Tarbague, Fabien Morote, et al.. Acoustic, electrochemical and microscopic characterization of interaction of Arthrospira platensis biofilm and heavy metal ions. Journal of Environmental Chemical Engineering, Elsevier, 2013, 1 (3), pp.609-619. ⟨10.1016/j.jece.2013.07.006⟩. ⟨hal-00878629⟩
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- Zhenzhong Guo, Nadia Zine, Patrick Balaguer, Aidong Zhang, Philippe Namour, et al.. Electrochemical estrogen receptor a based biosensor for label-free detection of estradiol. Electroanalysis, Wiley-VCH Verlag, 2013, 25 (7), pp.1765-1772. ⟨10.1002/elan.201300163⟩. ⟨hal-00924198⟩
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- Nadèje Tekaya, Olga Saiapina, Hatem Ben Ouada, Florence Lagarde, Hafedh Ben Ouada, et al.. Ultra-sensitive conductometric detection of pesticides based on inhibition of esterase activity in Arthrospira platensis.. Environmental Pollution, Elsevier, 2013, 178, pp.182-188. ⟨10.1016/j.envpol.2013.03.013⟩. ⟨hal-00851121⟩
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- Nadèje Tekaya, Olga Saiapina, Hatem Ben Ouada, Florence Lagarde, Hafedh Ben Ouada, et al.. Ultra-sensitive conductometric detection of heavy metals based on inhibition of alkaline phosphatase activity from Arthrospira platensis.. Bioelectrochemistry, Elsevier, 2013, 90, pp.24-29. ⟨10.1016/j.bioelechem.2012.10.001⟩. ⟨hal-00878619⟩
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- Thanhthuy Nguyen Boisse, Joëlle Saulnier, Nicole Jaffrezic-Renault, Florence Lagarde. Highly sensitive conductometric biosensors for total lactate, d- and l-lactate determination in dairy products. Sensors and Actuators B: Chemical, Elsevier, 2013, 179, pp.232-239. ⟨10.1016/j.snb.2012.10.021⟩. ⟨hal-00818875⟩
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2012
Journal articles
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- Mouna Hnaien, Sergei Dzyadevych, Florence Lagarde, Nicole Jaffrezic-Renault. A conductometric sensor specific for cationic surfactants. Electroanalysis, Wiley-VCH Verlag, 2012, 24 (6), pp.1441-1445. ⟨10.1002/elan.201200055⟩. ⟨hal-00818898⟩
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- W. Nouira, A. Maaref, Francis Vocanson, M. Siadat, Joëlle Saulnier, et al.. Enhancement of enzymatic IDE biosensor response using gold nanoparticles. Example of the detection of urea. Electroanalysis, Wiley-VCH Verlag, 2012, 24 (5), pp.1088-1094. ⟨ujm-00681963⟩
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2011
Journal articles
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- Camille Bleriot, Géraldine Effantin, Florence Lagarde, Marie-Andrée Mandrand-Berthelot, Agnès Rodrigue. RcnB Is a Periplasmic Protein Essential for Maintaining Intracellular Ni and Co Concentrations in Escherichia coli. Journal of Bacteriology, American Society for Microbiology, 2011, 193 (15), pp.3785-3793. ⟨10.1128/JB.05032-11⟩. ⟨hal-00818893⟩
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- Mouna Hnaien, Emilie Ruffin, Claire Bordes, Olivier Marcillat, Florence Lagarde, et al.. Integrity characterization of myoglobin released from poly(ε-caprolactone) microspheres using two analytical methods: UV/Vis spectrometry and conductometric bi-enzymatic biosensor. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2011, 78 (2), pp.298-305. ⟨10.1016/j.ejpb.2011.01.013⟩. ⟨hal-00703788⟩
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- Florence Lagarde, Nicole Jaffrezic-Renault. Cell-based electrochemical biosensors for water quality assessment. Analytical and Bioanalytical Chemistry, Springer Verlag, 2011, 400 (4), pp.947-964. ⟨10.1007/s00216-011-4816-7⟩. ⟨hal-00809749⟩
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- Mouna Hnaien, Florence Lagarde, Joan Bausells, Abdelhamid Errachid, Nicole Jaffrezic-Renault. A new bacterial biosensor for trichloroethylene detection based on a three-dimensional carbon nanotubes bioarchitecture. Analytical and Bioanalytical Chemistry, Springer Verlag, 2011, 400 (4), pp.1083-1092. ⟨10.1007/s00216-010-4336-x⟩. ⟨hal-00809762⟩
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- Naima Bouyahia, Mohamed Larbi Hamlaoui, Mouna Hnaien, Florence Lagarde, Nicole Jaffrezic-Renault. Impedance spectroscopy and conductometric biosensing for probing catalase reaction with cyanide as ligand and inhibitor. Bioelectrochemistry, Elsevier, 2011, 80 (2), pp.155-161. ⟨10.1016/j.bioelechem.2010.07.006⟩. ⟨hal-00703801⟩
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