Carole CHAIX

Doctor
work phone: 0437423557

Research

  • Development of rapid, low-cost and multiplexed assays for either in-situ analyses, point-of-care diagnostics and/or personalized medicine. Electrochemical sensors based on carbon or gold electrodes. Redox-labeled biomolecules for electrochemical detection.
  • Multi-functionalized nanoparticles for in vitro diagnostics and in vivo imaging and therapy.

Biography

Carole Chaix is Director of research at the Centre National de la Recherche Scientifique (CNRS). She graduated from the University of Grenoble where she obtained a Master in Biological and Medical Engineering in 1987 and a Ph.D. degree in 1990. She started her career as academic Researcher at the University of Montpellier in 1991. After four years in Montpellier and one year spent at the Hybridon company in Boston (US), where she was involved in the development of antisense oligonucleotides for cancer therapy, she moved to the Ecole Normale Supérieure de Lyon (ENS) to work in the CNRS-bioMérieux research unit. Her research activities were focused on the development of innovative approaches for in vitro diagnostics. In 2008, she joined the Institute of Analytical Sciences to work on biosensors.
Carole Chaix has a strong experience in developing innovative approaches, tools and devices for the detection of a wide range of biological targets (DNA, proteins, antibodies, bacteria,…). Her skills relate to biomolecule synthesis, labeling and immobilization on different supports. She is currently involved in the development of potential-assisted grafting reactions for addressing biomolecules on gold and carbonaceous materials. She is also interested in the elaboration of multi-functionalized nanoparticles for cancer therapy. She is currently co-author of over 65 publications (h-index = 18) and 8 patents.

Keywords

Biosensor; Bioconjugate; Nanotechnology; Interface; Electrochemical detection; multidetection; Methylene blue; Ferrocene; DNA; Nanomedicine; Nanostructuration; Diamond; Gold; Graphene; multi-functionalization;

Publications

Articles in peer-review journals  since 2011

Publications HAL de Carole,Chaix

2018

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David Kryza, Gabriel De Crozals, Doriane Mathé, Jacqueline Taleb Sidi-Boumedine, Marc Janier, et al.. Granulocyte-Colony Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part II): Dose-Dependent Biodistribution and In Vivo Antitumor Efficacy in Combination with Rituximab. Bioconjugate Chemistry, American Chemical Society, 2018, 29 (3), pp.804 - 812. 〈10.1021/acs.bioconjchem.7b00606〉. 〈hal-01767371〉
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Gabriel De Crozals, David Kryza, Gloria Jiménez Sánchez, Stéphane Roux, Doriane Mathé, et al.. Granulocyte Colony-Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part I): Synthesis and Biodistribution Studies. Bioconjugate Chemistry, American Chemical Society, 2018, 29 (3), pp.795 - 803. 〈10.1021/acs.bioconjchem.7b00605〉. 〈hal-01767382〉
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Ludivine Vossier, Lionel Valera, Fanny Leon, Stéphanie Roche, Dominique Piquer, et al.. Combining culture and microbead-based immunoassay for the early and generic detection of bacteria in platelet concentrates. Transfusion, Wiley, 2018, 〈10.1111/trf.15019〉. 〈hal-01934702〉
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Estelle Lebègue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Responsive polydiacetylene vesicles for biosensing microorganisms. Sensors, MDPI, 2018, 18 (2), pp. 599. 〈10.3390/s18020599〉. 〈hal-01740158〉
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Estelle Lebegue, Carole Farre, Catherine Jose, Joëlle Saulnier, Florence Lagarde, et al.. Biomimetic vesicles for electrochemical sensing. Current Opinion in Electrochemistry, Elsevier, 2018, 〈10.1016/j.coelec.2018.06.005〉. 〈hal-01928207〉
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Romaric Bonnet, Carole Farre, Lionel Valera, Ludivine Vossier, Fanny Leon, et al.. Highly labeled methylene blue-ds DNA silica nanoparticles for signal enhancement of immunoassays: application to the sensitive detection of bacteria in human platelet concentrates. Analyst, Royal Society of Chemistry, 2018, 143 (10), pp.2293-2303. 〈10.1039/c8an00165k〉. 〈hal-01859171〉
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2016

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Gabriel De Crozals, Romaric Bonnet, Carole Farre, Carole Chaix. Nanoparticles with multiple properties for biomedical applications: A strategic guide. Nano Today, Elsevier, 2016, 11 (4), pp.435-463. 〈10.1016/j.nantod.2016.07.002〉. 〈hal-01546542〉
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Mohamed Braiek, Yi Yang, Carole Farre, Carole Chaix, François Bessueille, et al.. Boron-doped Diamond Electrodes Modified with Fe 3 O 4 @Au Magnetic Nanocomposites as Sensitive Platform for Detection of a Cancer Biomarker, Interleukin-8.. Electroanalysis, Wiley-VCH Verlag, 2016, 28 (8), pp.1810-1816. 〈10.1002/elan.201600060〉. 〈hal-01546541〉
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2015

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Lucian-Gabriel Zamfir, Philippe Fortgang, Carole Farre, Micaël Ripert, Gabriel De Crozals, et al.. Synthesis and electroactivated addressing of ferrocenyl and azido-modified stem-loop oligonucleotides on an integrated electrochemical device. Electrochimica Acta, Elsevier, 2015, 164, pp.62-70. 〈10.1016/j.electacta.2015.02.167〉. 〈hal-01227342〉
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https://hal.archives-ouvertes.fr/hal-01227342/file/manuscript_ElecCell_ISA_vf.pdf BibTex

2014

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Nadir Meini, Micaël Ripert, Carole Chaix, Carole Farre, Gabriel De Crozals, et al.. Label-free electrochemical monitoring of protein addressing through electroactivated "click" chemistry on gold electrodes. Materials Science and Engineering: C, Elsevier, 2014, 38, pp.286-291. 〈10.1016/j.msec.2014.02.013〉. 〈hal-00954571〉
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2013

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Myriam Lereau, Chantal Fournier-Wirth, Julie Mayen, Carole Farre, Albert Meyer, et al.. Development of Innovative and Versatile Polythiol Probes for Use on ELOSA or Electrochemical Biosensors: Application in Hepatitis C Virus Genotyping. Analytical Chemistry, American Chemical Society, 2013, 85, pp.9204−9212. 〈10.1021/ac401941x〉. 〈hal-00874608〉
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Micaël Ripert, Carole Farre, Carole Chaix. Selective functionalization of Au electrodes by electrochemical activation of the "click" reaction catalyst. Electrochimica Acta, Elsevier, 2013, 91, pp.82-89. 〈10.1016/j.electacta.2012.12.108〉. 〈hal-00878554〉
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2012

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Gabriel De Crozals, Carole Farre, Grégoire Hantier, Didier Léonard, Christophe A. Marquette, et al.. Oligonucleotide solid-phase synthesis on fluorescent nanoparticles grafted on controlled pore glass. RSC Advances, Royal Society of Chemistry, 2012, 2 (31), pp.11858-11866. 〈10.1039/c2ra22077f〉. 〈hal-00816504〉
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N. Meini, Carole Farre, Carole Chaix, R. Kherrat, Sergei Dzyadevych, et al.. A sensitive and selective thrombin impedimetric aptasensor based on tailored aptamers obtained by solid-phase synthesis. Sensors and Actuators B: Chemical, Elsevier, 2012, 166, pp.715-720. 〈10.1016/j.snb.2012.03.046〉. 〈hal-00816495〉
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Grégory Chatelain, Micaël Ripert, Carole Farre, Salomé Ansanay-Alex, Carole Chaix. A "four-ferrocene" modified stem-loop structure as a probe for sensitive detection and single-base mismatch discrimination of DNA. Electrochimica Acta, Elsevier, 2012, 59, pp.57-63. 〈10.1016/j.electacta.2011.10.030〉. 〈hal-00698518〉
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2011

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Grégory Chatelain, Albert Meyer, François Morvan, Jean-Jacques Vasseur, Carole Chaix. Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate α-oligonucleotides. New Journal of Chemistry, Royal Society of Chemistry, 2011, 35 (4), pp.893-901. 〈10.1039/C0NJ00902D〉. 〈hal-00986717〉
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