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The group investigates the behavior of organic micro-pollutants with both targeted and untargeted analytical methods applied to environmental and health issues. It also aims to contribute to the understanding of Environment & Health interactions (exposome) and human exposure.

To fit these objectives, we develop:
Innovative methods for the quantification of trace and ultra-trace of contaminants, i.e. drugs, hormones, pesticides, endocrine disruptors (EDs), and of their transformation products and metabolites in environmental matrices: waters, soil, sediment, sludge, sentinel species,… All the steps of the analytical protocol: sampling, sample preparation, chromatographic separation, detection by mass spectrometry and data analysis (dSPE, SPE-LC-MS/MS online, micro-QuEChERS, nano-LC-MS/MS, LC-HRMS…) are optimized to evaluate the occurrence, degradation, transfert and bioaccumulation pathways in ecosystems.

New analytical methodologies for a comprehensive and untargeted analysis, i.e. without prior knowledge of marker substances. This analytical strategy in the environmental area combines the advantages of an effect-directed analysis complemented by a metabonomics approach to data processing.

For health issues, the combination of both targeted and non-targeted analytical strategies allows holistic approaches to improve the understanding of the Environment-Health interactions a recent concept known as the exposome. For this purpose, biologic fluids (urine, serum, plasma,…) are explored.

Recent highlights

  • Contribution to a national study on the occurrence of emerging pollutants and the potential risk for the aquatic media
  • Assessment of the accumulation potential of EDs in small aquatic invertebrates at individual level
  • First analytical method to monitor the extractability of additives and their degradation products into solutions or human fluids at trace levels from polymers used in packaging
  • Potential biomarkers of doping by metabonomic

Contact: Dr Emmanuelle VULLIET, Group leader – emmanuelle.vulliet@isa-lyon.fr