The six groups that constitute the axis all focus on the development of new methods in NMR spectroscopy aimed at applications that were impossible by any technique in area across domains from biology and medicine to materials sciences. We particularly target NMR for metabolism, especially in problems related to cancer ; structural biology and drug discovery ; powder crystallography ; surface science & catalysis.
We have a class-world instrumental platform, with 8 high-field NMR spectrometers equipped with multiple configurations, including two gyrotron DNP machines at 400 and 800 MHz and the unique 1 GHz NMR spectrometer in the world.
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The main objective of our work is to enable researchers in chemistry and biology to use nuclear magnetic resonance as a routine tool in order to obtain a structural and dynamic characterisation of chemical or biological systems of primary importance, from new materials to complex biological systems, such as metalloproteins and large biological assemblies of […]
Research of the Biophysics of complex systems group is currently dealing with the structural and dynamical study of biological systems by Nuclear Magnetic Resonance (NMR) and more particularly complex biomolecular assemblies. We are developing methodological tools to address biological questions, mainly centered on endocytosis. We also combine NMR with high performance computing based on the […]
The molecular interaction group investigates all kind of molecules in solution and more particularly focuses on the interaction of biomolecules as well as polymer NMR characterization. In particular, we are interested in combining experimental data with molecular dynamics through the use of GPU technology to assay the thermodynamical parameters describing molecular interactions. We focus on […]
Our research spans the field of Chemical Biology, Structural Biology and Drug Discovery and mainly focuses on the development of new molecules to fight cancer, inflammation, as well as infectious diseases through the development of novel antibiotics and antiviral compounds. Our approach is based on the combination of NMR spectroscopy and fragment library screening. We […]
The group’s research primarily focuses on the developing of computational methods for the characterization and understanding of the dynamics, interactions, and function of proteins and their complexes at the atomistic level by solution and solid-state nuclear magnetic resonance (NMR) spectroscopy. Yet, we are also actively developing new computational methods for analysis of complex mixtures for […]
The group NMR Methods for Metabolism develops a multi-disciplinary approach that combines development of state-of-the art NMR spectroscopic methods, statistical strategies for metabolomics NMR data analysis and applications of the metabolomics approach to functional and medical biology pertaining to cancer research, epidemiology and infectiology. To achieve our objectives for molecular fingerprinting of model organisms and […]
The group develops new approaches both for structural characterization of complex surfaces e.g. new functional materials for energy and catalysis, and for the determination of molecular structures from powders, such as pharmaceutical materials. The group currently progresses towards these challenges along two main directions: Dynamic nuclear polarization surface enhanced NMR. The group introduced a new […]
Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry. Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical […]