The groups and platforms that constitute the axis focus on:

  • Innovative approaches for the characterization and the deconvolution of sample complexity at different scales (elemental, isotopic, molecular) as well as at different steps of the analysis procedure
  • Multi-dimensional and multi-scale hyphenated methods (ie separative and detection methods) for complex matrices
  • Innovative sample preparation methods for ultra-trace analysis

Research targets issues across diverse areas such as omic sciences (metabolomics, proteomics, lipidomics), (bio)pharmacology, exposome, environment, bioenergies, chemistry, traceability and authenticity of natural and bio-sourced products.




Axis Managers

Groups – platforms

Biological Analysis by Mass Spectrometry

Biomarkers can be used to detect a change in the physiological state of a patient that correlates with the risk or progression of a disease (eg. Alzheimer’s disease) and/or to assess chemical exposure and the cumulative, adverse effects of toxicants in ecotoxicology. The discovery and the validation of new biomarkers raise many both analytical and […]


Chromatography & Hyphenated Techniques

The group develops chromatographic techniques from analytical to preparative scale, with a view to push the limits in terms of both separation power and sensitivity. i.e. Centrifugal Partition Chromatography (CPC or countercurrent chromatography), Ultra High Performance Liquid Chromatography (UHPLC) and Supercritical Fluid Chromatography (SFC) with a particular focus on multi-dimensional chromatography hyphenated to multi detection […]


Natural & Bio-based Products

The group develops large databases for the identification and authentication of natural and bio-based products as well as comprehensive multi-technique analyses in order to determine origins of contamination or to detect and quantify undesirable products especially in food, natural and bio-based products or environmental matrices. These methodologies have application within the fields of Agricultural and […]


Plasma spectroscopies, hyphenated methods & speciation

The “Plasma spectroscopies, hyphenated methods & speciation” group evaluates and develops spectroscopic tools and their hyphenations. Two main fields of research are investigated : speciation methods and laser assisted spectroscopy whose applications are related to process control, sustainable chemistry and environmental issues. Our work in laser assisted spectroscopy is mainly dedicated to: Instrumental and strategy […]



The group develops analytical methods, based on both targeted and untargeted approaches by mass spectrometry, to study the exposure of environmental ecosystems and human beings to organic micropollutants and their impact on Health. We develop innovative methods involving improvements at each step of the analytical protocol: sampling, sample preparation, chromatographic separation, detection by mass spectrometry […]


CISMALY platform

The Interdisciplinary Center in Mass Spectrometry at Lyon (CISMALY) is an open platform for research, service, consulting and training in mass spectrometry. CISMALY is hosted in the ISA’s buildings. Created by members of the units ILM and ISA, this platform is labelled and funded in part by the research federation “Institute of Chemistry of Lyon” […]


Isotopic & Organic

Stable isotope investigations are widely used to trace and understand biological or industrial processes. The Isotopic & Organic Group carries out innovative developments using stable isotopes measurements (2H/1H, 13C/12C, 15N/14N and 18O/16O) in different research programs with industrials and/or academic organisms. Analyzes are performed on gases (CO2, N2, H2, CO) using Isotope Ratio Mass Spectrometers […]